On October 25, 2021, Joe Burrow achieved a career-high with 416 passing yards and three touchdowns, while Ja’Marr Chase recorded 201 receiving yards, leading the Cincinnati Bengals to a commanding 41-17 victory over the Baltimore Ravens. This win propelled the Bengals to the top of the AFC North. Chase caught eight passes, including an 82-yard touchdown, and C.J. Uzomah contributed with 91 receiving yards and two touchdowns. Despite Lamar Jackson’s 257 passing yards and 88 rushing yards, the Bengals’ defense contained him, sacking him five times and ending the Ravens’ five-game winning streak.
In another notable game, Tom Brady threw for 211 yards and four touchdowns, including his 600th career touchdown pass, leading the Tampa Bay Buccaneers to a 38-3 rout over the Chicago Bears. Mike Evans caught three touchdown passes, and Chris Godwin added another for the Buccaneers, who improved to 6-1. Khalil Herbert rushed for 100 yards for Chicago, but rookie quarterback Justin Fields struggled with three interceptions and two fumbles.
Kyler Murray passed for 261 yards and three touchdowns, overcoming a slow start to lead the Arizona Cardinals to a 31-5 win against the Houston Texans. The Cardinals maintained their perfect record at 7-0 despite Murray being sacked four times and throwing an interception. The Texans, led by rookie quarterback Davis Mills, failed to score a touchdown for the third consecutive road game.
Ryan Tannehill and Derrick Henry led the Tennessee Titans to a dominant 27-3 victory over the Kansas City Chiefs. Tannehill threw for 270 yards, and Henry, the NFL’s leading rusher, added 86 yards and a touchdown pass. The Chiefs’ Patrick Mahomes was held to 206 passing yards with an interception and a fumble before being briefly sidelined for a concussion check.
The Los Angeles Rams outlasted the winless Detroit Lions 28-19 in a game featuring quarterbacks traded for each other. Matthew Stafford threw for 334 yards and three touchdowns for the Rams, while Jared Goff’s late interceptions thwarted the Lions’ comeback efforts.
Daniel Jones led the New York Giants to a 25-3 victory over the Carolina Panthers, throwing for 203 yards and a touchdown. The Giants’ defense dominated, limiting the Panthers to 173 total yards and forcing Carolina to replace quarterback Sam Darnold with PJ Walker in the fourth quarter.
Mac Jones threw for 307 yards and two touchdowns, guiding the New England Patriots to a 54-13 thrashing of the New York Jets. The Jets’ Zach Wilson left the game with a knee injury, and backup Mike White threw for 202 yards with a touchdown and two interceptions.
Aaron Rodgers passed for 274 yards and three touchdowns, leading the Green Bay Packers to a 24-10 win over Washington. The Packers’ defense made crucial stops inside their 5-yard line and intercepted Taylor Heinecke late in the game.
Younghoe Koo’s 36-yard field goal as time expired lifted the Atlanta Falcons to a 30-28 win over the Miami Dolphins. Falcons rookie tight end Kyle Pitts had a standout performance with 163 receiving yards.
Derek Carr passed for 323 yards and two touchdowns, leading the Las Vegas Raiders to a 33-22 victory over the Philadelphia Eagles. The Raiders improved to 5-2, while the Eagles fell to 2-5.
Carson Wentz accounted for three touchdowns as the Indianapolis Colts defeated the San Francisco 49ers 30-18 in a rain-soaked game. Wentz threw for 150 yards and two touchdowns, while Jonathan Taylor rushed for 107 yards and a score. The 49ers’ Jimmy Garoppolo threw for 181 yards with one touchdown and two interceptions.
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